Oxford will be without West Ham loanee Nathan Holland for the home clash with MK Dons.
The winger suffered a hamstring injury in the win over Shrewsbury and it could sideline him for the rest of the season.
Mark Sykes replaced Holland in last Saturday’s 3-2 victory and boss Karl Robinson could decide to give him the nod from the off against the Dons.
Liverpool loanee Ben Woodburn is back in contention – after recovering from a broken bone in his foot – alongside John Mousinho (knee), but Malachi Napa is not expected to play again this term as he continues rehabilitation from a broken leg sustained in August.
MK Dons boss Russell Martin has no new injury concerns for the trip.
Defender Dean Lewington and forward Carlton Morris returned for the 1-0 defeat at home to Doncaster last weekend.
Midfielder Ben Gladwin again caught the eye off the bench, with his cameo the latest in a number of promising displays.
The former Blackburn and QPR player had spent a long chunk of time out with a knee injury before joining the Dons in January, but is edging closer to his full debut.