Tom Huddlestone is expected to miss Derby’s home clash with Luton.
The midfielder hurt a hamstring in the process of scoring his first goal of the season from the penalty spot in the 2-2 draw at Barnsley in midweek.
Boss Phillip Cocu said: “We hope it is not too bad but if it is real damage he will probably be out for some time.”
Striker Jack Marriott is a doubt with a groin injury.
The Rams made two changes to their starting line-up against the Tykes, with Jayden Bogle coming in for the first time since August having recovered from an ankle problem and Tom Lawrence preferred to Florian Jozefzoon. They will hope to keep their places.
Luton have no fresh injury or suspension concerns for the trip.
The Hatters named an unchanged starting line-up and bench for the midweek draw at home to Millwall and came through the game unscathed.
Winger Callum McManaman came off the bench to grab a late equaliser against the Lions – his first goal for the club – and he will hope to feature more prominently.
Goalkeeper James Shea signed a new deal with the club this week, but he is likely to be on the bench once again at Pride Park.