MPs have voted 432 to 202 against Theresa May’s Brexit deal.
A majority of 230 means that it is the biggest government defeat in history.
Addressing the defeat, Mrs May said: “The House has spoken and the Government will listen. It is clear that the House does not support this deal but tonight’s vote tells us what it does support.
“Nothing about how or even if it intends to honour the decision in a referendum Parliament decided to hold.”
The PM said EU citizens in the UK and British expats living on the continent “deserve clarity on these questions as soon as possible”.
In the wake of the vote, Labour leader Jeremy Corbyn told the House of Commons that Mrs May’s “catastrophic” defeat represented an “absolutely decisive” verdict on her Brexit negotiations and said he has tabled a vote of confidence.
Mr Corbyn said the confidence vote would allow the Commons to “give its verdict on the sheer incompetence of this Government”.
It is scheduled to be debated and voted on tomorrow, with the DUP saying they will back the Prime Minister.
My word. 118 Tory MPs voted against their PM pic.twitter.com/Je1PWDOtaU
— Faisal Islam (@faisalislam) January 15, 2019
Responding to the vote, which took place just nine weeks before the UK is due to leave the EU, First Minister Nicola Sturgeon tweeted: “Historic defeat for the PM and it has been obvious for months that it was coming.
“Enough time has been wasted. It is time to stop the Article 50 clock and put this issue back to electorate. Scotland voted to remain in the EU and we should not be dragged out against our will.”
— Jean-Claude Juncker (@JunckerEU) January 15, 2019