Single fares will start at £19.99 and the flights will run six times a week. Outbound and return flights will be on offer on weekdays and Sunday.
This is the first non-chartered international route from Dundee Ariport.
It is the third route Flybe has announced under the UK government’s £7m regional air connectivity fund.
Inglis Lyon, managing director of Dundee Airport operator HIAL, said: “The new route offers business and leisure travellers fast, convenient links to hundreds of destinations worldwide and, crucially, creates new opportunities for inward investment and inbound tourism at an exciting time for the city.”